Research Unit on Pediatric Psychopharmacology

L. Eugene Arnold, M.D., M.Ed.

Professor Emeritus of Psychiatry
207 McCampbell Hall
arnold.6@osu.edu
(614) 292-9780

Group Email: psychmed@osu.edu

L. Eugene Arnold, M.D., M.Ed.

Dr. "Gene" Arnold is a child psychiatrist, educator, Professor Emeritus of Psychiatry, and a Principal Investigator in the psychopharmacology and related research program at the Ohio State University Nisonger Center. His recent professional publications dealing with child mental health and ADHD can be previewed in our resources section.

Education

University of Dayton, Dayton, OH
B.S. Biology & Chemistry (1959)

The Ohio State University
, Columbus, OH
M.D. College of Medicine, Summa cum Laude

Johns
Hopkins University, Baltimore, MD
Psychiatry Residency (1970)

Johns
Hopkins Evening College, Baltimore, MD
M.Ed. Education (1969)

Positions

  • 1966-68 Staff psychiatrist, St. Elizabeth's Hospital, Washington, D.C. (PHS)

  • 1970-73 Assistant Professor of Psychiatry & Pediatrics, Ohio State University

  • 1973-78 Associate Professor of Psychiatry & Pediatrics, Ohio State University

  • 1973-85 Director, Division of Child Psychiatry, Ohio State University College of Medicine

  • 1978-92 Professor of Psychiatry & Pediatrics, Ohio State University

  • 1985-92 Vice Chairman, Department of Psychiatry, Ohio State University

  • 1991-3/92 Scientific Advisor to Chief, Child & Adolescent Disorders Branch, National Institute of Mental Health, Intergovernmental Personnel Agreement

  • 3/92-3/96 Special Expert, Child & Adolescent Disorders Research Branch, National Institute of Mental Health

  • 1996-- Executive Secretary of steering committee, NIMH multi-site
    Multimodal Treatment Study of Children with ADHD (“MTA")

  • 1998-- Co-investigator, OSU Research Unit in Pediatric Psychopharmacology (RUPP), Chair, steering committee 2000-2008

Honors

  • Diplomate, Amer. Board Psychiatry/Neurology: Gen. Psychiatry, 1970, Certificate #10845; Child Psych, l97l, Certif. # Chi P 647.

  • Psychiatrist of the Year, Psychiatric Society of Central Ohio, 1992

  • NIH Director's Award for work on NIMH Multimodal Treatment Study of Children with ADHD, 1996

Selected Peer Reviewed Publications

Arnold, L.E.: Detection and management of hyperkinetic children in school. School Counselor 18, 177-184, 1971.

Arnold, L.E.: Control of aggression by advanced grade placement: Criteria and case history. Journal of School Health 42, 458-459, 1972.

Arnold, L.E., Strobl, D. & Weisenberg, A.: Hyperkinetic adult: Study of the paradoxical amphetamine response. Journal of the American Medical Association 222, 693-694, 1972.

Arnold, L.E., Wender, P.H., McCloskey, K. & Snyder, S.: Levoamphetamine and dextroamphetamine: Comparative efficacy in the hyperkinetic syndrome: Assessment by target symptom. Archives of General Psychiatry 27, 816-822, 1972.

Knopp, W., Arnold, L.E., Andras, R.A. & Smeltzer, D.: Electronic pupillography: Predicting amphetamine response in hyperkinetic children. Pharmakopsychiatrie 6, 158-166, 1972.

Arnold, L.E.: The art of medicating hyperkinetic children. Clinical Pediatrics. 12, 35-41, 1973.

Arnold, L.E., Kirilcuk, V., Corson, S.A. & Corson, E. O'L.: Levoamphetamine and dextroamphetamine: Differential effect on aggression and hyperkinesis in children and dogs. American Journal of Psychiatry 130, 165-170, 1973.

Arnold, L.E. & Smeltzer, D.: Factor analysis of behavior checklist for child psychiatry outpatients. Archives of General Psychiatry 30, 799-804, 1974. (Also in Inventory of Marriage and Family Literature, Vol. 3, 1974).

Arnold, L.E., Krebs, G. & Knopp, W.: Amphetamine treatment of paranoid obsessions: Case report and biochemical implications. Pharmakopsychiatrie 35, 322-327, 1974.

Huestis, R.D., Arnold, L.E. & Smeltzer, D.: Caffeine vs. methylphenidate and d-amphetamine in minimal brain dysfunction: A double-blind comparison. American Journal of Psychiatry 132:8, 1975. Abstracted in Pediatrics Digest, Sept. 1976.

Arnold, L.E., Huestis, R.D., Smeltzer, D., Scheib, J., Wemmer, D. & Colner, G.: Levoamphetamine vs. dextroamphetamine in MBD: Replication, time response and differential effect by diagnostic group and family rating. Archives of General Psychiatry 33(3):292-301, Mar. 1976. Abstracted in Psychiatry Digest, Oct. 1976.

Arnold, L.E.: Minimal brain dysfunction: A hydraulic parfait model. Diseases of the Nervous System 37(4), 171-173, 1976.

Arnold, L.E., Barnebey, N., McManus, J., Smeltzer, D., Conrad, A., Winer, G. & Desgranges, L.: Prevention by specific perceptual remediation for vulnerable first-graders: Controlled study and follow-up of lasting effects. Archives of General Psychiatry 34, 1279-1294, Nov. 1977.

Corson, E. O'L., Corson, S.A., Arnold, L.E. & Knopp, W.: Long-term elimination of violent behavior by the interaction of psychopharmacologic and psychosocial therapy. Activitas Nervosa Superior, 19(3), 216-219, 1977.

Bhatara, V., Arnold, L.E., Knopp, W. & Smeltzer, D.J.: A survey study of the use of electropupillogram in predicting response to psychostimulants. Psychopharmacology 57, 185-187, 1978.

Arnold, L.E., Huestis, R., Wemmer, D. & Smeltzer, D.: Differential effect of amphetamine optical isomers on Bender-Gestalt performance of the minimally brain dysfunctioned. Journal of Learning Disabilities 11:3, March, 1978.

Arnold, L.E., Christopher, J., Huestis, R. & Smeltzer, D.J.: Methylphenidate vs. d-amphetamine vs. caffeine in MBD: Controlled comparison by placebo washout design with Bayes analysis. Archives of General Psychiatry 35:463-473, April, 1978.

Bhatara, V., Clark, D. & Arnold, L.E.: Behavioral and nystagmus response of a hyperkinetic child to vestibular stimulation. The American Journal of Occupational Therapy, 32:5, May-June, 1978.

Dixon, K.N., Arnold, L.E. & Calestro, K.M.: Father-son incest: Unrecognized psychiatric disorder? American Journal of Psychiatry 135:7, July, 1978.

Arnold, L.E.: Megavitamins for MBD: A placebo-controlled study. Journal of American Medical Association 20:24, Dec. 1978.

Bhatara, V., Arnold, L.E., Lorance, T. & Gupta, D.: Muscle relaxation therapy in hyperkinesis: Is it effective? Journal of Learning Disorders 12:3, March, 1979.

Arnold, L.E., Sheridan, K.: Hyperactivity with tactile defensiveness as a phobia. Journal of School Health 50(9), 531-533, November, 1980.

Bhatara, V., Clark, D.L., Arnold, L.E., Gonsett, R., Smeltzer, D.J.: Hyperkinesis treated by vestibular stimulation: An exploratory study. Biological Psychiatry 16(3), 269-279, 198l.

Arnold, L.E., Barnebey, N.S., Smeltzer, D.J.: First grade norms, factor analysis and cross correlation for Conners, Davids & Quay-Peterson Behavior Rating Scales. Journal of Learning Disabilities 14(5), 269-275, May, 1981.

Frye, P.E. & Arnold, L.E.: Persistent Amphetamine-Induced Compulsive Rituals: Response to Pyridoxine (B6). Biological Psychiatry 16(6), 583-587,1981.

Arnold, L.E., Selinger, S.S. & Koizumi, H.: Limbic Regression with Derepression of Oedipal Feelings. The American Journal of Psychoanalysis, 41(1), 81-84, Spring, 1981.

Arnold, L.E.: Follow-up on a Follow-up Study: Pitfalls and Ethical Implications. Journal of Pediatric Psychology, 7:3, 345-348, 1982.

Box, J., Arnold, L.E. & Smeltzer, D.J.: Protriptyline Weight Loss in Compulsive Eaters: A Placebo-Controlled Study, Journal of Psychiatric Treatment and Evaluation 5, 387-391, 1983.

Arnold, L.E., Calestro, K., Bates, W., & Wasserman, M.: Teaching Psychiatric Interviewing as a Core Physician Skill, Journal of Psychiatric Education 7(1), 102-112, 1983.

Lynn, D.J., Mirkin, B.A., Lanese, D.M., Schmidt, H.S. & Arnold, L.E.: Correspondence between DSM-II hyperkinetic reaction and DSM-III attention deficit disorder, Journal of the American Academy of Child Psychiatry 22:4, 349-350, 1983.

Arnold, L.E.: Diet and Hyperkinesis, Integrative Psychiatry 2:5, 188-200, Sept-Oct, 1984.

Arnold, L.E., Clark, D.L., Sachs, L.A., Jakim, S. & Smithies, C.: Vestibular & Visual Rotational Stimulation as Treatment for Attention Deficit and Hyperactivity, The American Journal of Occupational Therapy 39:2, 84-91, February, 1985.

Houts, C.B., Turbett, J.A., Arnold, L.E., and Kruse, E.: Cost of Medical/Surgical Pediatric Hospital Days Preventable by Psychiatric Hospitalization, Journal of American Academy Child Psychiatry 24:2, 227-230, 1985.

Nemzer, E., Arnold, L.E., Votolato, N.A., McConnell, H.: Amino Acid Supplementation as Therapy for Attention Deficit Disorder (ADD), Journal of the American Academy of Child Psychiatry 25, 4:509-513, 1986.

Arnold, L.E., Sheridan, K. Estreigher, D.: Multifamily Parent-Child Group Therapy for Behavior and Learning Disorders, Journal of Child and Adolescent Psychotherapy 3(4): 279-284, 1986.

Arnold, L.E., Kleykamp, D., Votolato, N.A., Taylor, W.A., Kontras, S.B., Tobin, K.: Gamma-linolenic Acid for Attention-Deficit Hyperactivity Disorder: Placebo Controlled Comparison to d-amphetamine. Biological Psychiatry, 25:222-228, 1989.

Arnold, L.E., Votolato, N.A., Kleykamp, D., Baker, G.B., Bornstein, R.A.: Does hair zinc predict amphetamine improvement of ADHD/Hyperactivity? Inter. J. Neuroscience, 50:103-107, 1990.

Arnold, L.E. and Aman, M.G.: Beta-Blockers in Mental Retardation/ Developmental Disorders. Journal of Child and Adolescent Psychopharmacology, 1(5):361-373, 1991.

Arnold, L.E.: Quantifying the value of human life for cost accounting of safeguards: Clarifying formulas applied to the clozapine controversy as an example. The Journal of Clinical Ethics 3(1):103-108, 1992.

Aman, M.G., Kern, R.A., McGhee, D.E., & Arnold, L.E. Fenfluramine and methylphenidate in children with mental retardation and ADHD: clinical and side effects. J. of American Academy of Child & Adolescent Psychiatry, 32(4):851-859, 1993.

Arnold, L.E. Treatment Research Methodology Comparisons: Adult vs. Child & Adolescent, and Psychopharmacological vs. Psychosocial Treatments. Psychopharmacology Bulletin, 29(1):5-17, 1993.

Arnold, L.E. Clinical Pharmacological Issues in Treating Psychiatric Disorders of Patients with Mental Retardation. Annals of Clinical Psychiatry 5(3):189-197, 1993.

Arnold, L.E. Screening and evaluating alternative and innovative psychiatric treatments: A contextual framework. Psychopharmacology Bulletin 30(1):61-67, 1994.

Arnold, L.E., Kleykamp, D., Votolato, N., Gibson, R.A., & Horrocks, L. Potential link between dietary intake of fatty acids and behavior: Pilot Exploration of Serum lipids in ADHD. J. Child & Adolescent Psychopharmacology 4(3):171-180, 1994.

Arnold, L.E. Some nontraditional (unconventional and/or innovative) psychosocial treatments for children and adolescents: critique and proposed screening principles. J. Abnormal Child Psychology 23(1):125-140, 1995.

Richters, J.E., Arnold, L.E., Jensen, PS, Abikoff, HB, Conners, CK, Greenhill, LL, Hechtman, L, Hinshaw, SP, Pelham, WE, & Swanson, JM. The NIMH collaborative multisite multimodal treatment study of children with ADHD (MTA): I. Background & rationale. J. of Amer. Acad. Child & Adolesc. Psychiatry 34(8): 987-1000, 1995.

Arnold, L.E., Stoff, D., Cooke, E., Cohen, DJ, Kruesi, M, Wright, CB, Hattab, J, Graham, P, Zametkin, A, Castellanos, FX, McMahon, W, & Leckman, JF. Ethics of biological psychiatric research with children and adolescents. J. of Amer. Acad. Child & Adolesc. Psychiatry 34(7): 929-939, 1995.

Arnold, LE. Sex Differences in ADHD: Conference Summary. J. Abnormal Child Psychology, 24(5): 555-569, 1996.

Greenhill LL, Abikoff HB, Arnold LE, Cantwell DP, Conners CK, Elliott G, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, March JS, Newcorn JH, Pelham WE, Richters JE, Schiller EP, Severe JB, Swanson JM, Vereen D, Wells KC. Medication Treatment Strategies in the MTA: Relevance to Clinicians and Researchers. J. of Amer. Acad. Child & Adolesc. Psychiatry, 35(10):1304-1313, 1996.

Arnold LE, Hoagwood K, Jensen PS, Vitiello B. Towards clinically relevant clinical trials. Psychopharm Bull 33(1): 135-142, 1997.

Hinshaw, S.P., March, J.S., Abikoff, H., Arnold, L.E., Cantwell, D.P., Conners, C.K., Elliott, G.R., Halperin, J., Greenhill, L.L., Hechtman, L.T., Hoza, B., Jensen, P.S., Newcorn, J.H., McBurnett, K., Pelham, W.E., Richters, J.E., Severe, J. B., Schiller, E., Swanson, J.M., Vereen, D., Wells, K., & Wigal, T. (1997). Comprehensive assessment of childhood attention-deficit hyperactivity disorder in the context of a multisite, multimodal clinical trial. Journal of Attention Disorders 1(4):217-234, January, 1997.

Arnold LE, Abikoff HB, Cantwell DP, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, March JS, Newcorn JH, Pelham WE, Richters JE, Schiller EP, Severe JB, Swanson JM, Vereen D, Wells KC. NIMH Collaborative Multimodal Treatment Study of Children With ADHD (MTA): Design Challenges and Choices. Archives of Gen. Psychiatry 54:865-870, September, 1997.

Arnold LE, Abikoff HB, Cantwell DP, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, March JS, Newcorn JH, Pelham WE, Richters JE, Schiller EP, Severe JB, Swanson JM, Vereen D, Wells KC. NIMH Collaborative Multimodal Treatment Study of Children With ADHD (MTA): Design, Methodology, and Protocol Evolution. J. Attention Disorders 2:141-158, Oct., 1997.

Arnold, LE. Treatment alternatives for attention-deficit/hyperactivity disorder (ADHD). Journal of Attention Disorders, 3:30-48, 1999.

March JS, Conners CK, Arnold LE, Epstein J, Parker S, Hinshaw S, Abikoff H, Molina B, Wells K, Newcorn J, Schuck S, Pelham WE, Hoza B. The Multidimensional Anxiety Scale for Children (MASC): Confirmatory factor analysis in a pediatric ADHD sample. J. Attention Disorders 3(2): 85-90, July, 1999.

The MTA Cooperative Group (incl. L.E. Arnold). A 14-Month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 56:1073-1086, Dec. 1999.
The MTA Cooperative Group (incl. L.E. Arnold). Moderators and mediators of treatment response for children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 56:1088-1096, Dec. 1999.

Arnold LE. Methylphenidate vs. Amphetamine: Comparative Review. J. Attention Disorders, 3(4):200-211, 2000.

Aman MG, Arnold LE, Armstrong S. Review of Serotonergic Agents and Perseverative Behavior in Patients with Developmental Disabilities. Mental Retardation and Developmental Disabilities Research Reviews 5:279-289, 1999.

Arnold LE, Aman MG, Martin A, Collier-Crespin A, Vitiello B, Tierney E, Asarnow R, Bell-Bradshaw F, Freeman BJ, Gates-Ulanet P, Klin A, McCracken JT, McDougle CJ, McGough JJ, Posey DJ, Scahill L, Swiezy NB, Ritz L, Volkmar F. Assessment in multisite randomized clinical trials (RCTs) of patients with autistic disorder: The Autism RUPP network. J. Autism and Developmental Disorders 30(2):99-111, 2000.

Arnold LE, Pinkham SM, Votolato N. Does zinc moderate essential fatty acid and amphetamine treatment of attention-deficit/hyperactivity disorder? J. Child & Adolescent Psychopharmacology 10(2):111-117, 2000.

Hoza B, Owens JS, Pelham WE, Swanson JM. Conners CK, Hinshaw SP, Arnold LE, Kraemer HC. Parent Cognitions as Predictors of Child Treatment Response in Attention-Deficit/Hyperactivity Disorder. J. Abnormal Child Psychology, 28(6):569-583, 2000.

Hinshaw SP., Owens EB., Wells KC., Kraemer HC., Abikoff HB., Arnold LE., Conners CK., Elliott G., Greenhill LL., Hechtman L., Hoza B., Jensen PS., March JS., Newcorn JH, Pelham WE., Swanson JM., Vitiello B, & Wigal T. Family Processes and Treatment Outcome in the MTA: Negative/Ineffective Parenting Practices in Relation to Multimodal Treatment. J. Abnormal Child Psychology, 28(6):555-568, 2000.

Epstein, JN, Conners, CK, Erhardt, D, Arnold, LE, Hechtman, L, Hinshaw, SP, Hoza, B, Newcorn, JH, Swanson, JM, & Vitiello, B. Familial Aggregation of ADHD Characteristics. Journal of Abnormal Child Psychology, 28(6):585-594, 2000.

Wells KC, Pelham WE, Kotkin RA, Hoza B, Abikoff HB, Abramowitz A, Arnold LE, Cantwell DP, Conners CK, Del Carmen R, Elliott GR, Greenhill LL, Hechtman L, Hibbs E, Hinshaw SP, Jensen PS, March JS, Schiller E, Swanson JM. Psychosocial Treatment Strategies in the MTA Study: Rationale, Methods, and Critical Issues in Design and Implementation. J. Abnormal Child Psychology, 28(6):483-505, 2000.

March, JS, Swanson, JM, Arnold, LE, Hoza, B, Conners, CK, Hinshaw, S, Hechtman, L, Kraemer, HC, Greenhill, LL, Abikoff, HB, Elliott, G, Jensen, PS, Newcorn, JH, Vitiello, B, Newcorn, J, Severe, JB, Wells, KC, Pelham, WE. Anxiety as a Predictor and Outcome Variable in the Multimodal Treatment Study of Children with ADHD. J. Abnormal Child Psychology, 28(6):527-541, 2000.

Wells, CK, Epstein, JN, Hinshaw, SP, Conners, CK, Klaric, J, Abikoff, HB, Abramowitz, A, Arnold, LE, Elliot, G, Greenhill, LL, Hechtman, L, Hoza, B, Jensen, PS, March, JS, Pelham, WE, Pfiffner, L, Severe, J, Swanson, J, Vitiello, B, Wigal, T. Parenting and Family Stress Treatment Outcomes in Attention Deficit Hyperactivity Disorder (ADHD): An empirical analysis in the MTA study. J. Abnormal Child Psychology, 28(6): 543-553 2000.
Swanson JM, Kraemer HC., Hinshaw, SP, Arnold, LE, Conners, CK, Abikoff, HB, Clevenger W, Davies M, Elliott, G, Greenhill, LL, Hechtman, L, Hoza, B, Jensen, PS, March, JS, Newcorn JH, Owens L, Pelham, WE, Schiller E, Severe, J, Simpson S, Vitiello, B, Wells, CK, Wigal, T, Wu, M. Clinical Relevance of the Primary Findings of the MTA: Success Rates Based on Severity of ADHD and ODD Symptoms at the End of Treatment. J. Amer. Acad. Child & Adolesc. Psychiatry, 40:168-179, 2001.

Conners CK., Epstein JN., March JS., Angold A., Wells KC., Klaric J., Swanson JM., Abikoff HB., Arnold LE., Elliott GR., Greenhill LL., Hechtman L., Hinshaw SP., Hoza B., Jensen PS., Kraemer HC., Newcorn J., Pelham WE., Severe JB., Vitiello B., Wigal T. Multimodal treatment of ADHD in the MTA: an alternative outcome analysis J. Amer. Acad. Child & Adolesc. Psychiatry, 40:159-167, 2001.

Greenhill LL, Swanson JM., Vitiello B., Davies M., Clevenger W., Wu M., Severe JB., Arnold LE., Abikoff HB, Conners CK., Elliott G., Hechtman L., Hinshaw SP., Hoza B., Jensen PS, Kraemer HC., March JS., Newcorn JH., Pelham WE., Wells K., Wigal T (2001). Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration. J. Amer. Acad. Child & Adolesc. Psychiatry 40:180-187, 2001.

Vitiello B., Severe JB., Greenhill LL., Arnold LE., Abikoff HB., Bukstein O, Elliott GR., Hechtman L., Jensen PS., Hinshaw SP., March JS., Newcorn JH., Swanson JM., and Cantwell DP. Methylphenidate Dosage for Children with ADHD over Time under Controlled Conditions: Lessons from the MTA. J. Amer. Acad. Child & Adolesc. Psychiatry, 40:188-196, 2001.
Newcorn JH., Halperin JM., Jensen PS., Abikoff HB., Arnold LE., Cantwell DP., Conners CK., Elliott GR., Epstein J., Greenhill LL., Hechtman L., Hinshaw SP., Hoza B., Kraemer HC., Pelham WE., Severe JB., Swanson JM., Wells KC., Wigal T., Vitiello B. Symptom Profiles in Children with Adhd: Effects of Comorbidity and Gender. J. Amer. Acad. Child & Adolesc. Psychiatry, 40:137-146, 2001.

Jensen PS., Hinshaw SP., Kraemer HC., Lenora N., Newcorn JH., Abikoff HB., March JS., Arnold LE., Cantwell DP., Conners CK., Elliott GR., Greenhill L.L., Hechtman L., Hoza B., Pelham WE., Severe JB., Swanson JM., Wells KC., Vitiello B., Wigal T. ADHD Comorbidity Findings From the MTA Study: Comparing Comorbid Subgroups. J. Amer. Acad. Child & Adolesc. Psychiatry, 40:147-158, 2001.

Arnold LE. Ingestive treatments for learning disorders. Perspectives 27:18-21, 2001.

Arnold, LE. Alternative Treatments for Adults with ADHD. in: Wasserstein J, Wolfe LE, & Lefever FF, eds.: Adult Attention Deficit Disorders: Brain mechanisms and Life Outcomes. NY: New York Academy of Sciences, PP.310-341, 2001.

Arnold, LE. Turn-of-the-century ethical issues in child psychiatric research. Current Psychiatry Reports 3:109-114, 2001.
Jensen PS, Hinshaw SP, Swanson JM, Greenhill LL, Conners CK, Arnold LE, Abikoff HB, Elliott G, Hechtman L, Hoza B, March JS, Newcorn JH, Pelham WE, Severe JB, Vitiello B, Wells KC, Wigal T: "Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): Implications and Applications for Primary Care Providers." J Dev. Behav. Pediatrics, 22:60-73, 2001.

Scahill L, McCracken J, McDougle CJ, Aman M, Arnold LE, Tierney E, Cronin P, Davies M, Ghuman J, Gonzalez N, Koenig K, Lindsay R, Martin A, McGough J, Posey DJ, Swiezy N, Volkmar F, Ritz L, Vitiello B: Methodological issues in designing a multisite trial of risperidone in children and adolescents with autism. J. Child & Adolescent Psychopharmacology 11(4):377-388, 2002.

Abikoff HB, Arnold LE, Newcorn J, Elliott G, Hechtman L, Severe JB, Wigal T, Shapiro C, Cantwell DP, Conners CK, Greenhill LL, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, March JS, Pelham WE, Swanson JM, Vitiello B, Wells KC (2002). Emergency/adjunct services and attrition prevention for randomized clinical trials in children: The MTA manual-based solution. J. Amer. Acad. Child & Adolesc. Psychiatry, 41(5):498-504.

Rieppi, R., Greenhill, L. L., Ford, R. E., Chuang, S., Wu, M., Davies, M., Abikoff, H., Arnold, L. E., Conners, C. K., Elliott, G., Hechtman, L., Hinshaw, S., Hoza, B., Jensen, P., Kraemer, H. C., Newcorn, J., Pelham, W., Severe, J., Swanson, J., Vitiello, B., Wells, K., Wigal, T. (2002). Socioeconomic status as a moderator of ADHD treatment outcomes. J Am Acad Child Adolesc Psychiatry, 41(3), 269-277.

Abikoff HB., Jensen PS., Arnold LE., Hoza B., Hechtman L., Pollack S., Martin D., Alvir J., March JS., Hinshaw S., Vitiello B., Newcorn J., Greiner A., Cantwell DP., Conners CK., Elliott G., Greenhill LL., Kraemer H., Pelham WE., Severe JB., Swanson JM., Wells K., Wigal T. (2002). Observed Classroom Behavior of Children with ADHD: Relationship to Gender and Comorbidity. J. Abnormal Child Psychology, 30:349-359.

Swanson JM, Arnold LE, Vitiello B, Abikoff H, Wells KC, Pelham WE, March JS, Hinshaw SP, Hoza B, Epstein JN, Elliott GR, Greenhill LL, Hechtman L, Jensen PS, Kraemer HC, Kotkin R, Molina B, Newcorn JH, Owens EB, Severe JB, Simpson S, Wigal T. Response to Commentary on the Multimodal Treatment Study of ADHD (MTA): Mining the Meaning of the MTA. J. Abnormal Child Psychology 30:327-332, Aug. 2002.

Research Units on Pediatric Psychopharmacology (RUPP) Autism Network (McCracken JT, McGough J, Shah B, Cronin P, Hong D, University of California at Los Angeles; Aman MG, Arnold LE, Lindsay R, Nash P, Hollway J, Ohio State University; McDougle CJ, Posey D, Swiezy N, Kohn A, Indiana University; Scahill L, Martin A, Koenig K, Volkmar F, Carroll D, Lancor A, Yale University; Tierney E, Ghuman J, Gonzalez NM, Grados M, Kennedy Krieger Institute; Vitiello B, Ritz L, National Institute of Mental Health; Davies M, Columbia University; Robinson J, McMahon D, Nathan Kline Institute). Randomized clinical trial of risperidone for irritability in autism. New England Journal of Medicine, 2002, 347 (5) 314-321.

Aman, M.G., Buican, B., & Arnold, L.E. Methylphenidate treatment in children with low IQ and ADHD: Analysis of three aggregated studies. J. Child & Adolescent Psychopharmacology, 13(1):29-40, 2003.

Galanter CA, Carlson GA, Jensen PS, Greenhill LL, Davies M, Li W, Shirley Z. Chuang, SZ, Elliott GR, Arnold LE, March JS, Hechtman L, Pelham WE, Swanson, JM. 2003. Response to Methylphenidate in Children with ADHD and Manic Symptoms in the MTA Titration Trial. J Child & Adol Psychopharmacology 71(3), 540-552.

Arnold L.E., Elliott M., Sachs L, Bird H, Kraemer HC, Wells KC, Abikoff HB, Comarda A, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Jensen PJ, March JS, Newcorn J, Pelham WE, Severe JB, Swanson JM, Vitiello B, Wigal T. Effects of Ethnicity on Treatment Attendance, Stimulant Response/dose, and 14-month Outcome in ADHD. Journal of Consulting and Clinical Psychology, 71(4):713-727, 2003.

Owens, E. B., Hinshaw, S. P., Kraemer, H. C., Arnold, L. E., Abikoff, H. B., Cantwell, D P., Conners, C. K., Elliot, G., Greenhill, L. L., Hechtman, L., Hoza, B., Jensen, P. S., March, J. S., Newcorn, J. H., Pelham, W. E., Richters, J. E., Schiller, E. P., Severe, J. B., Swanson, J. M., Vereen, D., Vitiello, B., Wells, K. C., & Wigal, T. What treatment for whom for ADHD: Moderators of treatment response in the MTA. Journal of Consulting and Clinical Psychology, 71(3), 540-552, 2003.

Arnold LE, Vitiello B, McDougle CJ, Scahill L, Shah B, Gonzalez NM, Chuang S, Davies M, Hollway J, Aman MG, Cronin P, Koenig K, Kohn AE, McMahon DJ, Tierney E. Parent-defined Target Symptoms Respond to Risperidone in RUPP Autism Study: Customer Approach to Clinical Trials. J. Amer. Acad. Child & Adolesc Psychiatry, 2003 Dec.; 42(12):1443-1450.

Stevens, L., Zhang, W., Peck, L., Kuczek, T., Grevstad, N., Mahon, A., Zentall, S.S., Arnold, L. E., and J. R. Burgess (2003) Polyunsaturated fatty acid supplementation in children with inattention, hyperactivity and other disruptive behaviors. Lipids 38:1007-1021.

Arnold L.E., Chuang S, Davies M, Kraemer HC, Abikoff HB, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Jensen PJ, March JS, Newcorn J, Pelham WE, Severe JB, Swanson JM, Vitiello B, Wells KC, Wigal T. Nine Months of Multicomponent Behavioral Treatment for ADHD and Effectiveness of MTA Fading Procedures. J. Abnormal Child Psychology, 32(1):39-51, 2004.

The MTA Cooperative Group (incl. L.E.Arnold). The NIMH MTA Follow-up: 24-month Outcomes of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder (ADHD). Pediatrics 2004, 113(4):754-761.

The MTA Cooperative Group (incl. L.E.Arnold). The NIMH MTA Follow-up: Changes in Effectiveness and Growth After the End of Treatment. Pediatrics 2004, 113(4):762-769.

Martin, A., Scahill, L., Anderson, G.M., Aman, M., Arnold, L.E., McCracken, J., McDougle, C.M., Tierney, E., Chuang, S., Vitiello, B., and the Research Units on Pediatric Psychopharmacology Autism Network: Weight and Leptin Changes among Risperidone-Treated Youths with Autism: Six-Month Prospective Data. American Journal of Psychiatry 2004; 161:1125-1127.

Hoza, B., Gerdes, A. C., Hinshaw, S. P., Arnold, L. E., Pelham, W. E., Molina, B. S. G., Abikoff, H. B., Epstein, J. N., Greenhill, L. L., Hechtman, L., Odbert, C., Swanson, J. M., Wigal, T. (2004). Self-perceptions of competence in children with ADHD and comparison children. Journal of Consulting and Clinical Psychology, 72, 382-391.

Jensen PS, Hoagwood K, Roper M, Arnold LE, Odbert C, Crowe M, Molina BS, Hechtman L, Hinshaw SP, Hoza B, Newcorn J, Swanson J, Wells K. (2004). The Services for Children and Adolescents--Parent Interview (SCAPI): Development and Performance Characteristics. Journal of the American Academy of Child & Adolescent Psychiatry, 43(11):1334-1344.

Hoagwood K, Jensen P, Arnold LE, Roper M, Severe J, Odbert C, Molina BS, and the MTA Cooperative Group. (2004). Reliability of the Services for Children and Adolescents --Parent Interview (SCAPI). Journal of the American Academy of Child & Adolescent Psychiatry, 43(11):1345-1354.

Arnold LE, Lindsay RL, Conners CK, Wigal S, Levine AJ, Johnson DE, West SA, Sangal RB, Bohan TP, Zeldis JB. A double-blind placebo-controlled withdrawal trial of dexmethylphenidate hydrochloride in children with attention-deficit/hyperactivity disorder. J. Child & Adolescent Psychopharmacology, 14(4):542-554, 2004.

Vitiello B, Aman MG, Scahill L, McCracken JT, McDougle CJ, Tierney E, Davies M, Arnold LE: Research knowledge among parents of children participating in a randomized clinical trial. J Am Acad Child Adolesc Psychiatry 2005; 44:1-5.

Hoza, B., Gerdes, A. C., Mrug, S., Hinshaw, S. P., Bukowski, W. M., Gold, J. A., Arnold, L. E., Abikoff, H. B., Conners, C. K., Elliott, G. R., Greenhill, L. L., Hechtman, L., Jensen, P. S., Kraemer, H. C., March, J. S., Newcorn, J. H., Severe, J. B., Swanson, J. M., Vitiello, B., Wells, K. C., & Wigal, T. (2005). Peer-assessed outcomes in the Multimodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder. Journal of Clinical Child and Adolescent Psychology, 34, 74-86.

Hoza, B., Mrug,S., Gerdes, A.C., Hinshaw, S.P., Bukowski, J.M., Gold, J., Kraemer, H.C., Pelham, W.E, Wigal, T., Arnold, L.E. What Aspects of Peer Relationships are Impaired in Children With ADHD? J. Consulting and Clinical Psychology, in press, 2005.

McDougle, C.J., Scahill, L., Aman, M.G., McCracken, J.T., Tierney, E., Davies, M., Arnold, L.E., Posey, D.J., Martin, A., Ghuman, J.K., Shah, B., Chuang, S.Z., Swiezy, N.B., Gonzalez, N.M., Hollway, J., Koenig, K., McGough, J., Ritz, L., Vitiello, B.: Risperidone for the core symptom domains of autism: Results from the RUPP Autism Network Study. Am J Psychiatry, in press.

Epstein, J.N., Willoughby, M., Valencia, E.Y., Tonev, S.T., Abikoff, H.B., Arnold, L.E., & Hinshaw, S.P. (in press). The role of children's ethnicity in the relationship between teacher ratings of ADHD and observed classroom behavior. Journal of Consulting and Clinical Psychology.

RUPP Autism Network (incl. L.E. Arnold). Risperidone Treatment of Autistic Disorder: Longer Term Benefits and Blinded Discontinuation After Six Months American J. Psychiatry , in press, 2004.

Jensen PS, Garcia JA, Glied S, Crowe M, Foster M, Schlander M, Hinshaw S, Vitiello B, Arnold LE, Elliott G, Hechtman L, Newcorn J, Pelham WE, Swanson J, Wells K. Cost-effectiveness of ADHD TreatmentsFindings from the MTA Study. Am J Psychiatry, in press, 2005.

Langworthy-Lam K, Aman MG, Arnold LE. Neurochemical correlates of autistic disorder: a review of the literature. Research in Developmental Disabilities in press, 2005.

Epstein, J.N., Conners, C.K., Hervey, A.S., Tonev, S.T., Arnold, L.E., Abikoff, H.B., Elliott, G., Greenhill, L.L., Hechtman, L., Hoagwood, K., Hinshaw, S.P., Hoza, B., Jensen, P.S., Kraemer, H.C., March, J.S., Newcorn, J.H., Pelham, W.E., Severe, J.B., Swanson, J.M., Wells, K., Vitiello, B., & Wigal, T. (in press). Assessing Medication Effects in the MTA Study using Neuropsychological Outcomes. Journal of Child Psychology and Psychiatry.

Arnold LE, Bozzolo H, Hollway J, Cook, A, DiSilvestro R, Bozzolo D, Crowl L, Ramadan Y, Williams C. Serum zinc correlates with parent/teacher-rated inattention in children with attention-deficit/hyperactivity disorder. J. Child & Adolescent Psychopharmacology 15(4): 628-636.


Arnold LE, DiSilvestro R. Zinc in attention-deficit.hyperactivity disorder. J. Child & Adolescent Psychopharmacology 15(4): 619-627

Hervey, A., Epstein, J.N., Curry, J.F., Tonev, S., Arnold, L.E., Conners, C.K., Hinshaw, S.P., Swanson, J.M., & Hechtman, L. (in press). Reaction time distribution analysis of neuropsychological performance in an ADHD sample. Child Neuropsychology.